Cancer cell derived extracellular traps
WebNational Center for Biotechnology Information WebApr 14, 2024 · Surprisingly, single-cell RNA sequencing of pancreatic cancer cells revealed that circulating tumor cells (CTCs) in the blood upregulate expression of common stroma-derived ECM proteins like collagens (Col1a2, Col3a1), TIMP-2, the proteoglycan decorin (Dcn), the glycoprotein osteonectin (Sparc), and fibronectin (Ting et al. 2014). It is yet ...
Cancer cell derived extracellular traps
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WebAdrover et al. discuss the bidirectional interplay between neutrophil extracellular traps (NETs) and cancer, review how vascular dysfunction and thrombosis caused by … WebOct 14, 2015 · The discovery of neutrophil extracellular traps has yielded a conceptual framework for interpreting how extracellular DNA may function in cancer development and why it may prove to be an important clinical …
WebApr 27, 2024 · Extracellular DNA Traps: Origin, Function and Implications for Anti-Cancer Therapies Front Oncol. 2024 Apr 27;12:869706. doi: 10.3389/fonc.2024.869706. …
WebOct 19, 2016 · Neutrophils’ normal function is to kill harmful microorganisms in three ways: (i) phagocytosis, a process whereby bacteria or fungi are engulfed and digested; (ii) degranulation of cytotoxic enzymes into the extracellular space; and (iii) neutrophil extracellular traps (NETs), which are DNA meshes with associated cytotoxic enzymes … WebApr 10, 2024 · The tumor microenvironment can confer chemotherapy resistance (chemoresistance), but little is known about how specific host cells influence therapy …
WebNeutrophil extracellular traps (NETs), in addition to their function as a host defense mechanism, play a relevant role in thrombus formation and metastatic dissemination of cancer cells. Here we screened different cancer cell lines endogenously expressing a variety of integrins for their ability to bind to NETs. To this end, we used NETs isolated …
WebNeutrophil extracellular traps (NETs) have been considered a significant unfavorable factor for wound healing in diabetes, but the mechanisms remain unclear. The therapeutic application of small extracellular vesicles (sEVs) derived from mesenchymal stem cells (MSCs) has received considerable attention for their properties. pct blsWebMay 6, 2024 · Neutrophil extracellular DNA traps promote pancreatic cancer cells migration and invasion by activating EGFR/ERK pathway Wei Jin,1 ,2 Huijing Yin,3 Hao Li,2 Xian‐Jun Yu,2 Hua‐Xiang Xu,2 and Liang Liu2 Wei Jin 1Shanghai Institute of Immunology, Department of Immunology and Microbiology, pct bluetooth headphonesWebNETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps Cancer Cell. 2024 Feb 18;S1535-6108 (23)00011-9. doi: 10.1016/j.ccell.2024.02.001. Online ahead of print. Authors Jose M Adrover 1 , Sheri A C McDowell 2 , Xue-Yan He 1 , Daniela F Quail 3 , Mikala Egeblad 4 Affiliations scss1006sWebFormation of extracellular traps (ETs) was first thought to be restricted to neutrophils, as stimulation of peripheral blood mononuclear cells did not induce the release of similar … scss0810sWebMay 20, 2024 · Background: Emerging evidences have highlighted the roles of neutrophils, as the major host microenvironment component, in the development of hepatocellular carcinoma (HCC). Neutrophils extracellular traps (NETs) produced in the infection can strengthen the behavior of cancer metastasis. pct bifenthrinWebOct 1, 2024 · Neutrophil extracellular traps (NET) are the extracellular release of decondensed chromatin and granules known for their role in host defense against foreign pathogens. However, a novel and predominantly pro-tumorigenic role of NETs in cancer is emerging. Tumors induce NET formation through the secretion of an array of tumor and … pct bitterWeb1. Introduction. Neutrophils are an integral part of the immune system’s first line of defense against foreign organisms. Neutrophils’ antimicrobial properties encompass three processes: phagocytosis, degranulation, and release of neutrophil extracellular traps (NETs) [1,2,3].NETs are large cell-derived structures composed of decondensed chromatin, … scss0812clb3