Corynebacterium daptomycin
WebDaptomycin, a last-line-of-defense antibiotic for treating Gram-positive infections, is experiencing clinical failure against important infectious agents, including Corynebacterium striatum. The recent transition of daptomycin to generic status is projected to dramatically increase availability, use, and clinical failure. WebAug 29, 2016 · Nondiphtheria Corynebacterium species are often dismissed as culture contaminants, but they have recently become increasingly recognized as pathologic organisms. We present the case of a 48-year-old male patient on chronic prednisone therapy for rheumatoid arthritis with a history of mitral valve replacement with prosthetic …
Corynebacterium daptomycin
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WebMolecular epidemiology and clinical significance of Corynebacterium striatum isolated from clinical specimens Jin Woong Suh,1 Yongguk Ju,2 Chang Kyu Lee,3 Jang Wook Sohn,1,2 Min Ja Kim,1,2 Young Kyung Yoon1,2 1Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea; … WebDaptomycin, a last-line-of-defense antibiotic for treating Gram-positive infections, is experiencing clinical failure against important infectious agents, including …
WebMar 1, 2005 · Daptomycin has a unique mechanism of action that results in destruction of the membrane potential. The rapid bactericidal activity of daptomycin makes it an attractive antibiotic for serious Gram-positive infections. ... daptomycin is also potent against Corynebacterium jeikeium, and a variety of anaerobic species including … WebRecently Goldner et al. [4] further demonstrated that loss-of-function mutations in PG synthase (pgsA2) and the loss of membrane PG were necessary and sufficient to produce high-level resistance to daptomycin in Corynebacterium striatum. We have found that daptomycin, in the presence of Ca 2+ and PG membranes, forms a dimeric complex …
WebOct 12, 2016 · Daptomycin was rarely formally tested in our laboratory during this period (n = 6), including the 2 patients we previously described . Initial MICs for daptomycin were 0.032–0.125 mg/L, but it was rarely used by clinicians in our cohort. ... Emergence of high-level daptomycin resistance in Corynebacterium striatum in two patients with left ... WebThe objective of this study was to investigate the observation of daptomycin resistance in Corynebacterium striatum, both in vivo and in vitro. We describe a case of C. striatum bacteremia in a patient with a left ventricular assist device (LVAD); the initial isolate recovered was daptomycin susceptible with a minimum inhibitory concentration ...
WebJun 18, 2024 · Vancomycin should be used as the antibiotic of choice for the treatment of C. striatum infections, in monotherapy or in combination with piperacillin-tazobactam. …
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