Cyclophosphamide induced cardiomyopathy
WebNov 15, 2024 · Cardiomyopathy can be separated into primary (genetic, mixed, or acquired) and secondary categories, which result in varied phenotypes including dilated, … WebApr 30, 2024 · Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac …
Cyclophosphamide induced cardiomyopathy
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WebNational Center for Biotechnology Information Webcyclophosphamide cardiac toxicity as the literature relies on case reports in which the dose of cyclophosphamide admin-istered is variable, and the drug is often administered in the presence of other cardiotoxins.9,11,18-22 Risk Factors for Cyclophosphamide-Induced Cardiomyopathy The lack of clearly defined predictive variables for cyclo-
WebAfter C57BL/6 mice were treated with intermediate- and high-dose (25/50 mg/kg) cyclophosphamide (CTX) for 10 days, the body-weight, changes in thymus and spleen, number of white blood cells (WBCs), red blood cells (RBCs), and platelets (PLTs) and changes in bone marrow in the mice were systematically evaluated at the next 2, 7 and … WebFeb 7, 2024 · Martin M, Fornecker LM, Marcellin L, et al. Acute and fatal cardiotoxicity following high-dose cyclophosphamide in a patient undergoing autologous stem cell transplantation for systemic sclerosis despite satisfactory cardiopulmonary screening. Bone Marrow Transplant 2024; 52 (12): 1674–1677. Crossref PubMed Google Scholar 14.
Cyclophosphamide’s cardiotoxic mechanism is unknown but is believed to result in endothelial dysfunction and coronary artery vasospasms. This action typically leads to LVD, which progresses to pericarditis or hemorrhagic myocarditis. 5. Mabs: Trastuzumab and pertuzumab are recombinant humanized Mabs … See more The different types of cardiotoxicity include reversible, irreversible, acute, chronic, and late-onset. Irreversible damage is categorized as type 1 and reversible damage as type 2. Type 1 (direct damage) is usually caused by … See more Anthracyclines: The management of cardiotoxicity has primarily revolved around treating anthracycline toxicity; however, there are other approaches to reduce the risk of cardiac cell death.4 Recent studies have … See more Many chemotherapy agents cause cardiotoxicity, and their use requires close monitoring as well as counseling. Many of these agents have dosing-adjustment parameters, and the pharmacist can play a vital role in verifying … See more Cardiac monitoring is recommended in all patients before initiation of chemotherapeutic agents. Patients receiving anthracyclines and trastuzumab should have cardiac-function monitoring at baseline; months 3, … See more
WebMesenchymal stromal cells inhibit NLRP3 inflammasome activation in a model of Coxsackievirus B3-induced inflammatory cardiomyopathy [Pubmed:29434214] ... The effect of O-1602, a GPR55 agonist, on the cyclophosphamide-induced rat hemorrhagic cystitis [Pubmed: 32615180] Frontiers in Bioengineering and Biotechnology:
WebJan 1, 2013 · Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac … list of florida nursing schools on probationWebJan 10, 2024 · Cyclophosphamide-induced activation of p53 protein is considered as one of the possible mechanisms for cardiomyopathy, and it is reported that probucol supplementation restored cyclophosphamide … list of florida notariesWebJan 1, 2013 · Cyclophosphamide has been used for several decades, but the pathophysiology of cyclophosphamide-induced cardiac toxicity remains poorly understood. The minimum dose for cardiac toxicity is still … list of florida newspapersWebApr 12, 2024 · Haploidentical allogeneic stem cell transplantation with post-transplant cyclophosphamide and subsequent kidney transplant for patients with severe sickle cell disease with end-stage kidney... imagine that clarion iowaWebAbstract. A 17-year-old man with mediastinal seminoma was treated with chemotherapy and mediastinal irradiation therapy. Then he received high-dose chemotherapy containing … imagine that childcare fairbanks akWebMar 3, 2024 · Six months later, lupus myocarditis developed. After treatment with glucocorticoids, cyclophosphamide, intravenous immunoglobulin, and an intra-aortic balloon pump, she showed dramatic improvement. Patients with DIL and an immunological predisposition, such as anti-dsDNA antibodies, may have SLE and should be carefully … imagine that clothing storeWebAlthough cyclophosphamide is relatively well tolerated at lower doses, high-dose regimens such as those given with bone marrow transplantation can be associated with a variety of adverse effects. 10 However, the total dose of an individual course, rather than the cumulative dose, seems to be the best predictor of acute cardiotoxicity. 11 Prior … imagine that bead store poulsbo wa