WebCyanine phosphoramidites (Cy3, Cy3.5, Cy5, Cy5.5 analogs) Alkyne phosphoramidites; Tetramethyl rhodamine phosphoramidite (TAMRA) HEX; ... GalNAc CPG allows the synthesis of siRNA-GalNAc conjugate. 500Å and 10 00Å are available. The price is on request. N-acetylgalactosamine (GalNAc) is a well-defined liver-targeted moiety … WebOligonucleotides containing GalNAc can be deprotected using standard procedures during which the acetyl protecting groups on the GalNAc group are removed. We have demonstrated that 5’-GalNAc C3 phosphoramidite can be used to prepare oligonucleotides with multiple consecutive GalNAc additions at the 5’ terminus.
Less Is More: Novel Hepatocyte-Targeted siRNA ... - ScienceDirect
WebApr 30, 2024 · Here we provide a robust protocol for the synthesis of triple GalNAc CPG solid support and GalNAc phosphoramidite that can be used in standard automated oligonucleotide synthesis to introduce multiple GalNAc residues either to 5′-end or 3′-end of native or chemically modified DNA and RNA oligonucleotides (Fig. 1). The first sections … WebSep 15, 2024 · GalNAc is a well-known ligand of the asialoglycoprotein receptor (ASGPR), and is classified as a C-type lectin associated with the metabolism of desialylated glycoproteins. This article describes the synthesis of a non-nucleosidic monovalent GalNAc phosphoramidite—a useful reagent for facilitating the conjugation of GalNAc epitopes … qtac scholarship
Glen Report 29.14 - N-acetylgalactosamine (GalNAc) …
WebJan 1, 2016 · GalNAc phosphoramidite (compound 1) was synthesized from N-acetylgalactosamine in 6 steps and an overall yield of 12%. 10, 13 GalNAc-conjugated ASO is composed of one or several monovalent GalNAc sugar units (orange) attached by short tethers (blue) to ASO through a pyrrolidine linker (green). The potency of these … http://buyolig.com/controlled-pore-glass/galnac-cpg WebWe are glad to offer you a GalNAc phosphoramidite (LK2568) and two equivalent GalNAc solid supports, with a choice between two different pore sizes (LK2440 and LK2489). Our … qtac rural access scheme