2024 Sunitinib solubility dcm

Sunitinib solubility dcm

Author: ejnk

August undefined, 2024

WebNational Center for Biotechnology Information WebAug 7, 2024 · In mRCC patients who received sunitinib 50 mg/day according to the 4/2 schedule, four soluble biomarkers of sunitinib activity were investigated on days 1 and 28 of each cycle (Deprimo et al., 2007). At the end of the first cycle, plasma concentrations of VEGF and placental growth factor (PlGF) were increased, whereas those of soluble …

ANNEX I SUMMARY OF PRODUCT …

WebSunitinib is a yellow to orange powder soluble in acidic aqueous solutions (pH 1.2 – 6.8) at 25mg/ml. The solubility of sunitinib rapidly decreases at pH greater than 6.8. For this … WebSunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib … reheat french fries

Sunitinib malate-loaded biodegradable microspheres for the …

WebThe CHMP adopted a report on similarity of Sunitinib Accord with SomaKit, Lutathera and AYVAKYT on (Appendix 1) 10 December 2024 . 2. Scientific discussion 2.1. Introduction 2.2. Quality aspects 2.2.1. Introduction The finished product is presented as hard capsules containing 12.5, 25, 37.5 or 50 mg of sunitinib . Other ingredients are: WebSunitinib C22H27FN4O2 CID 5329102 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity … WebSunitinib is supplied as a lyophilized powder. For a 5 mM stock, reconstitute the 10 mg in 3.76 ml DMSO. Working concentrations and length of treatment can vary depending on … process simulation online

Z 3H 1H H FN O C H O - Food and Drug Administration

National Center for Biotechnology Information

WebSunitinib is a potent inhibitor of colony-stimulating factor-1 receptor kinase in an enzyme assay, with an IC50 value of 7 nM, and inhibits receptor phosphorylation in a cellular assay … WebNov 10, 2024 · Material Name: Sunitinib Malate Capsules Trade Name: SUTENT Chemical Family: Mixture Relevant Identified Uses of the Substance or Mixture and Uses Advised … process simulation and refinementWebApr 1, 2024 · Sunitinib malate is a synthetic indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity chemically designated as N - [2- (diethylamino)ethyl]-5- [ ( Z )- (5-fluoro-2-oxo-1 H -indol-3-ylidene)methyl]-2,4-dimethyl-1 H -pyrrole-3-carboxamide It has the molecular formula C 22 H 27 FN 4 O 2, with a molecular … reheat fried chicken keep crispy in microwave

"WebIn patients who received sunitinib in Phase 3 registrational studies, pulmonary events (i.e. dyspnoea, pleural effusion, pulmonary embolism, or pulmonary oedema) were reported … " - Sunitinib solubility dcm

Sunitinib solubility dcm

An improved synthesis of sunitinib malate via a solvent-free ...

WebAs the trifluoroacetate salt increased the solubility of 16 in DCM, ... Compd. 54 is more potent than sunitinib not only against FLT3-WT AML cells but also active against sunitinib-resistant FLT3-ITD AML cells. This study demonstrates the significance of dual Aurora B/FLT3 inhibitors for the development of potential agents to treat AML.

Did you know?

WebNov 11, 2024 · Sunb-malate has limited solubility in DCM, but can be dissolved in DMSO up to 100 mg/mL. The Sunb-malate DMSO solution and PLGA DCM solution were mixed at 1:4 ratio to form a homogeneous organic phase, which was used to prepare Sunb-malate MS using the emulsion solvent evaporation method. WebMar 1, 2024 · Solubility determination, various solubility parameters and solution thermodynamics of sunitinib malate in some cosolvents, water and various (Transcutol + …

WebFood and Drug Administration WebSunitinib(SU-11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFR? with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.; ... 7.85E-012 mm Hg (25 deg C, Mod-Grain method) Water Solubility Estimate from Log Kow (WSKOW v1.41): Water Solubility at 25 deg C (mg/L): 17.93 log Kow used: 2.63 (estimated) no-melting pt equation ...

WebMelting point: –97.1 °C Density: d 4 201.327 g/mL Solubility: Slightly soluble (1.38 g/100 mL) in water at 20 °C; soluble in carbon tetrachlo- ride; miscible in ethanol, diethyl ether, and dimethylformamide Volatility: Vapour pressure, 58.2 kPa at 25 °C; relative vapour density (air = 1), 2.93 (Verschueren, 1996) WebMar 13, 2015 · Application: Sunitinib Malate is an antineoplastic agent, Flk-1 inhibitor, and ATP-competitve inhibitor of PDGFRβ CAS Number: 341031-54-7 Purity: ≥97% Molecular Weight: 532.56 Molecular Formula: C 26 H 33 FN 4 O 7 For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WebNov 10, 2024 · Sunitinib malate 341031-54-7 Not Listed STOT RE. 1 (H372) Repr 1B (H360D) Aquatic Acute 1 (H400) Acute Chronic 1 (H410) 15-40 Magnesium stearate 557-04-0 209-150-3 Not Listed * ... Solvent Solubility: No data available Water Solubility: No data available pH: No data available.

WebSunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA on January 26, 2006. Mechanism of action. Sunitinib is a small molecule that inhibits multiple RTKs, some of which are implicated in tumor growth, pathologic angiogenesis, and metastatic progression of cancer. process simulation pharmaWebApr 6, 2024 · Moreover, due to its poor water solubility, protein binding, and accumulation in liver tissue, it is difficult to compare sunitinib malate—the commercial formulation—with the hydrochloride salt used in DEB . Nevertheless, Fuchs et al. demonstrated that sunitinib (2 mg/kg) tumor delivery via DEB increased the intratumoral concentration up to ... reheat fried fish for crispnessWebNov 11, 2024 · Sunb-malate has limited solubility in DCM, but can be dissolved in DMSO up to 100 mg/mL. The Sunb-malate DMSO solution and PLGA DCM solution were mixed at … process simulation free softwareWebSolubility: Soluble in DMSO at 40 mg/mL; soluble in ethanol at 1.4 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 … process simulation programsWebSolubility (25°C) DMSO 15 mg/mL Water <1 mg/mL Ethanol <1 mg/mL Storage Description Sunitinib Malate (Sutent, SU11248) is a potent RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, respectively. Targets VEGFR2 (Flk-1) PDGFRβ IC50 80 nM 2 nM [1] In vitro Sunitinib also potently inhibits Kit and FLT-3. process simulation in pharmaWebSunitinib malate salt is a photosensitive yellowish powder soluble in DMSO, whereas very poorly soluble in ethanol and water. Several methods of sunitinib synthesis are included in this review. UV spectroscopy of sunitinib showed a λmax of approximately 430 nm, whereas IR spectroscopy of sunitinib base were reported at 3298, 3230, 2968, 1676 ... reheat fried fish microwaveWebMar 1, 2024 · Recently, it has also been studied as a potential solubilizer in the solubility enhancement of various poorly soluble drugs, including sunitinib malate, flufenamic acid, sinapic acid, apremilast ... process simulation psychology